Profesor Wolfgang Schuhmann: The design of electrified interfaces: From amperometric biosensors to DNA hybridization
Lecture Type
Year
2014
The design of electrified interfaces: From amperometric biosensors to
DNA hybridization
For a rational design of biodevices comprising either redox enzymes or
nucleic acids as specific recognition element for selective detection of
an analyte the nature of the used electrode/electrolyte interface has to
be elucidated. Specifically, this is of utmost importance if a
polyelectrolyte such as single-stranded DNA is immobilized within the
double-layer in front of an electrode. Evidently, the applied electrode
potential, additional components at the interface as well as the
strength and nature of the electrolyte largely determine the properties
of the biological recognition element. The lecture is spanning a bridge
from interface design and electroanalytical techniques for elucidation
of interfacial properties to the development of pathogen assays and
multi DNA sensors.
DNA hybridization
For a rational design of biodevices comprising either redox enzymes or
nucleic acids as specific recognition element for selective detection of
an analyte the nature of the used electrode/electrolyte interface has to
be elucidated. Specifically, this is of utmost importance if a
polyelectrolyte such as single-stranded DNA is immobilized within the
double-layer in front of an electrode. Evidently, the applied electrode
potential, additional components at the interface as well as the
strength and nature of the electrolyte largely determine the properties
of the biological recognition element. The lecture is spanning a bridge
from interface design and electroanalytical techniques for elucidation
of interfacial properties to the development of pathogen assays and
multi DNA sensors.
