A paper from the Department of Biophysical Chemistry and Molecular Oncology is once again headed to an Elsevier journal.

28. 11. 2023

What has been gained from research into the possibility of using N-methyl mesoporphyrin IX (NMM) as a probe for electrochemical detection? This is what the group around Assoc. Prof. Miroslav Fojta, PhD. from the Department of Biophysical Chemistry and Molecular Oncology in an article in the journal Bioelectrochemistry.

In this work, the potential use of N-methyl mesoporphyrin IX (NMM) as a probe for the electrochemical detection and study of G-quadruplexes, stable DNA secondary structures that play a role in the regulation of important biological processes, was investigated. The results of this work showed that G-quadruplexes can be detected using this newly developed method and distinguished from other DNA structures based on their differential adsorption on the surface of the working electrode. This method also gave researchers the ability to observe the gradual formation of G-quadruplex structures with efficiency comparable to conventional CD spectroscopy methods, but with less experimental material consumption.

The full article can be found in the link HERE