Colorectal carcinoma probably starts with impairment of gut epithelium by unhealthy lifestyle and bad nutrition. One of the risk factors is, according to the World Health Organisation, also shift work. Using a mouse model, we study how

• the impairment of inner biological clock
• the impairment of natural rhythm day/night
• and the unhealthy exposure to the light during night periods

contribute to the development of colorectal carcinoma. Understanding of the mechanisms that connect the circadian clock and cell cycle regulation in the process of carcinogenesis is important for the prevention (avoiding damaging influences in the environment) as well as treatment.

In general, cancer cells typically alter their energy metabolism. Therefore, we also study specific bioenergetic features of cancer cells, which is the first step on the path to finding a treatment for cancer.

 

A sample of colorectal carcinoma is obtained by laser microdissection from a histological preparation of gut epithelium.

 

Scientific laboratories:

LABORATORY OF MEMBRANE TRANSPORT

LABORATORY OF EPITHELIAL PHYSIOLOGY

LABORATORY OF BIOLOGICAL RHYTHMS