The Laboratory of Experimental Hypertension is studying the mechanisms of blood pressure regulation and end-organ damage in rats with different types of experimental hypertension.
Our research is focused mainly on:
- Study of the central mechanisms of blood pressure regulation in rats with hypertension with a focus on the brain renin-angiotensin system, oxidative stress and baroreflex control of sympathetic tone – cooperation with the Institute for Translational Research in Biomedicine, Kaohsiung, Taiwan and Institute for Clinical and Experimental Medicine, Prague.
- Search for the cardiovascular, renal and metabolic mechanisms of gliflozins, a new group of antidiabetics, in experimental hypertension and chronic kidney disease – cooperation with Institute for Clinical and Experimental Medicine, Prague.
- Investigation on the cardiovascular effects of new analogs of neuropeptides regulating food intake in rats in connection with their neuroprotective effects in Alzheimer disease – cooperation with IOCHB CAS, Prague.
- Study of the role of sympathetic nervous system, renin-angiotensin system and glucocorticoids in modulation of cardiovascular stress response.
Projects
Achievements
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Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague) in collaboration with Institute of Physiology of the CAS developed new compounds with positive effects in experimental animal models of obesity and type II diabetes.
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Our colleagues were very successful at 26th International Meeting of International Society of Hypertension in Seoul - Michal Behuliak was awarded by the 2nd place in the section Young Investigator Award, Anna Vavřínová by Travel Grant and Josef Zicha was awarded by the 2nd place in the section Best Oral Presentation in Basic Sciences.
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Michal Behuliak was granted by the Czech Society for Hypertension, the price was awarded by the general manager of Servier in the Czech Republic.
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Publications
Řezáčová; Lenka - Vaněčková; Ivana - Hojná; Silvie - Vavřínová; Anna - Valovič; Pavol - Rauchová; Hana - Behuliak; Michal - Zicha; Josef
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Both central sympathoexcitation and peripheral angiotensin II-dependent vasoconstriction contribute to hypertension development in immature heterozygous Ren-2 transgenic rats
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Hypertension Research. 2022; 45(3); 414-423
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IF = 3.872
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Zicha; Josef - Behuliak; Michal - Vavřínová; Anna - Dobešová; Zdenka - Kuneš; Jaroslav - Rauchová; Hana - Vaněčková; Ivana
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Cooperation of augmented calcium sensitization and increased calcium entry contributes to high blood pressure in salt-sensitive Dahl rats
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Hypertension Research. 2021; 44(9); 1067-1078
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IF = 3.872
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doi
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Zicha; Josef
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Contribution of Sympathetic Nervous System to High Blood Pressure in Salt Hypertensive Dahl Rats
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Physiological Research. 2021; 70(2); 117-118
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IF = 1.881
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Vavřínová; Anna - Behuliak; Michal - Vaněčková; Ivana - Zicha; Josef
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The abnormalities of adrenomedullary hormonal system in genetic hypertension: their contribution to altered regulation of blood pressure
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Physiological Research. 2021; 70(3); 307-326
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IF = 1.881
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doi
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Rauchová; Hana
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Coenzyme Q10 Effects in Neurological Diseases
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Physiological Research. 2021; 70(Suppl.4); S683-S714
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IF = 1.881
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doi
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Pražienková; V. - Funda; Jiří - Pirník; Z. - Karnošová; A. - Hrubá; L. - Kořínková; L. - Neprašová; B. - Janovská; Petra - Bencze; Michal - Kadlecová; Michaela - Blahoš; J. - Kopecký; Jan - Železná; B. - Kuneš; Jaroslav - Bardová; Kristina - Maletínská; L.
GPR10 gene deletion in mice increases basal neuronal activity; disturbs insulin sensitivity and alters lipid homeostasis
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Gene. 2021; 774(Mar 30)); 145427
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IF = 3.688
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doi
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Pirník; Z. - Kořínková; L. - Osacká; J. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Cholecystokinin System Is Involved in the Anorexigenic Effect of Peripherally Applied Palmitoylated Prolactin-Releasing Peptide in Fasted Mice
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Physiological Research. 2021; 70(4); 579-590
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IF = 1.881
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doi
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Neckář; Jan - Alánová; Petra - Olejníčková; Veronika - Papoušek; František - Hejnová; L. - Šilhavý; Jan - Behuliak; Michal - Bencze; Michal - Hrdlička; Jaroslav - Vecka; M. - Jarkovská; D. - Švíglerová; J. - Mistrová; E. - Štengl; M. - Novotný; J. - Ošťádal; Bohuslav - Pravenec; Michal - Kolář; František
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Excess ischemic tachyarrhythmias trigger protection infarction in rats
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Clinical science. 2021; 135(17); 2143-2163
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IF = 6.124
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doi
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Mráziková; L. - Neprašová; Barbora - Mengr; A. - Popelová; A. - Strnadová; V. - Holá; L. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Lipidized Prolactin-Releasing Peptide as a New Potential Tool to Treat Obesity and Type 2 Diabetes Mellitus: Preclinical Studies in Rodent Models
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Frontiers in Pharmacology. 2021; 12(Nov 18)); 779962
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IF = 5.811
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doi
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Mengr; A. - Hrubá; L. - Exnerová; A. - Holubová; M. - Popelová; A. - Železná; B. - Kuneš; Jaroslav - Maletínská; L.
Palmitoylated Prolactin-releasing Peptide Reduced A? Plaques and Microgliosis in the Cerebellum: APP/PS1 Mice Study
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Current Alzheimer Research. 2021; 18(8); 607-622
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IF = 3.498
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Overview of alterations in calcium sensitization during development of spontaneously hypertension in the rat The schematic representation of possible regulatory mechanisms involved in RhoA/Rho kinase pathway is demonstrated in normotensive (a), prehypertensive (b) and hypertensive (c) rats.
Recording of contraction of isolated femoral artery stimulated by norepinephrine (NE).
Aorta section – α-actin (red), nuclei (blue) and autofluorescence (green).
Adrenal section stained for tyrosine hydroxylase (detected by Vectastain ABC kit).
Recording of blood pressure.