Metabolic syndrome is defined as the co-occurrence of several risk factors for type 2 diabetes and cardiovascular disease: mainly obesity, insulin resistance, high triglyceride and LDL cholesterol levels, and hypertension. These risk factors are determined by many genes with small effects and their interactions with environmental factors. Genome-wide association studies have so far revealed only a small fraction of the heritability of complex pathophysiological traits in humans. Thus, analyses of animal models of human complex diseases may represent a useful alternative. The department's research is focused on the following projects:
- Uncovering genes regulating hemodynamic and metabolic traits in the SHR strain.
- Analysis of the mechanisms underlying the development of salt sensitive hypertension.
Projects
Publications
Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Liška; František - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Mušálková; D. - Stránecký; V. - Kmoch; S. - Sticová; E. - Vrbacký; Marek - Mráček; Tomáš - Pravenec; Michal
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Spontaneous nonsense mutation in the tuftelin 1 gene is associated with abnormal hair appearance and amelioration of glucose and lipid metabolism in the rat
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Physiological Genomics. 2024; 56(1); 65-73
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IF = 4.6
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Marková; I. - Malínská; H. - Hüttl; M. - Kazdová; L. - Kazantsev; D. - Mancini; M. - Novotný; J. - Pravenec; Michal
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CD36 regulates substrates utilisation in brown adipose tissue of spontaneously hypertensive rats: In vitro study
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PLoS ONE. 2023; 18(4)); e0283276
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IF = 3.7
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doi
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Šilhavý; Jan - Mlejnek; Petr - Šimáková; Miroslava - Malínská; H. - Marková; I. - Hüttl; M. - Miklánková; D. - Kazdová; L. - Vrbacký; Marek - Pecinová; Alena - Mráček; Tomáš - Pravenec; Michal
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Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome
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Metabolites. 2023; 13(2)); 192
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IF = 4.1
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doi
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Kurtz; T. W. - Morris Jr.; R. C. - Pravenec; Michal - Lujan; H. L. - DiCarlo; S. E.
Hypertension in Primary Aldosteronism Is Initiated by Salt-Induced Increases in Vascular Resistance With Reductions in Cardiac Output
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Hypertension. 2023; 80(5); 1077-1091
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IF = 8.3
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doi
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Hüttl; M. - Marková; I. - Miklánková; D. - Zapletalová; I. - Kujal; P. - Šilhavý; Jan - Pravenec; Michal - Malínská; H.
Hypolipidemic and insulin sensitizing effects of salsalate beyond suppressing inflammation in a prediabetic rat model
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Frontiers in Pharmacology. 2023; 14(3 Apr)); 1117683
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IF = 5.6
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doi
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