3rd  BIOCEV-Krč Methodological Seminar

Topic: Selected Approaches in Genetic Toxicology

Monday 4^th March 2019 at 13:00 in the Turquoise Lounge (IEM)

Genetic toxicology investigates the impact of chemical, biological or physical agents on organisms. Modifications of macromolecules (DNA, lipids, proteins) are evaluated using biomarkers, measurable changes of selected parameters associated with the exposure. The exposure to chemical compounds may originate from the ambient air, water, soil, or food. Air pollution caused by vehicular traffic has many negative health effects, particularly in urban areas. Thus, it is important to monitor biological consequences of such exposure and reduce emissions production and exhaust toxicity. In this seminar we will first provide a general introduction to methods in genetic toxicology; then we will focus on air pollution associated with combustion engine emissions and the application of DNA damage detection methods.

The talks will be given by the following speakers:

RNDr. Pavel Rössner, PhD., Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology

Introduction to genetic toxicology: sources of air pollution, biological impacts, and their assessment

doc. Michal Vojtíšek, M.S., Ph.D., Czech Technical University, Centre of Vehicles for Sustainable Mobility

 Working towards realistic assessment of health effects of combustion engine emissions reduction efforts: real-world emissions, unregulated pollutants, and exhaust toxicity

Mgr. Andrea Rössnerová, PhD., Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology

DNA damage detection: analysis of chromosomal aberrations

Mgr. Ing. Táňa Závodná, Institute of Experimental Medicine CAS, Department of Genetic Toxicology and Nanotoxicology

The comet assay: a method for DNA strand breaks detection