Kalendář akcí
Zobrazit všeX
Naši vědci v médiích – výběr z článků, rozhovorů, reportáží
Publikace
Všechny publikace
Sulfonated Hydroxyaryl-Tetrazines with Increased pKa for Accelerated Bioorthogonal Click-to-Release Reactions in Cells
Angewandte Chemie International Edition 2024: Early View
Bioorthogonal reactions that enable switching molecular functions by breaking chemical bonds have gained prominence, with the tetrazine-mediated cleavage of trans-cyclooctene caged compounds (click-to-release) being particularly noteworthy for its high versatility, biocompatibility, and fast reaction rates. Despite several recent advances, the development of highly reactive tetrazines enabling quantitative elimination from trans-cyclooctene linkers remains challenging. In this study, we present the synthesis and application of sulfo-tetrazines, a class of derivatives featuring phenolic hydroxyl groups with increased acidity constants (pKa). This unique property leads to accelerated elimination and complete release of the caged molecules within minutes. Moreover, the inclusion of sulfonate groups provides a valuable synthetic handle, enabling further derivatization into sulfonamides, modified with diverse substituents. Significantly, we demonstrate the utility of sulfo-tetrazines in…
Triptycene-Based Tripodal Molecular Platforms
Chemistry - A European Journal 2024: Early View
Epitaxial Guidance of Adamantyl-Substituted Polythiophenes by Self-Assembled Monolayers
ACS Omega 9 (37): 38733–38742 (2024)
Structure and function of bacterial transcription regulators of the SorC family
Transcription 2024: Early View
Transformation of 5-acylated N-fluoroalkyl-1,2,3-triazoles to trifluoromethylated ring-fused isoquinolines, 1,3-oxazines, and 1,3-oxazin-6-ones via ketenimines
RSC Advances 14 (37): 26938-26942 (2024)