Dr. Antonín Ambrož from the Institute of Experimental Medicine of the AS CR will present the results of the project titled “Healthy Aging in Industrial Environment". The presented data are focused on analyzing contaminants that affect oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns. The talk will be given on-line on February 5th, 2024 at 2:30 p.m. Join Zoom Meeting https://cesnet.zoom.us/j/93563225963

The impact of environmental pollution to oxidative stress in mothers/newborns

Dr. Antonín Ambrož

Institute of Experimental Medicine AS CR, v.v.i.

Abstract:

The project “Healthy Aging in Industrial Environment” (HAIE) was carried out in 2018-2022. The partial aim of the study was to analyze contaminants that affect oxidative DNA damage and lipid peroxidation in non-smoking mothers and their newborns. 147 pairs of mothers/newborns originated from Ceske Budejovice (CB; an agricultural region) and 201 pairs were recruited from Karvina (an industrial region). Personal and medical data, external (PM2.5, B[a]P) and internal (PCBs, OCPs, BFRs, PFASs and OH-PAHs) exposures, antioxidant mechanisms (SOD, CAT, GPx and ORAC), and cytokines concentrations (IL-1β, IL-6) were investigated as parameters potentially affecting the markers of DNA oxidation (8-oxo-7,8-dihydro-2’-deoxyguanosine) and lipid peroxidation (15-F2t-isoprostane).

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