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Pracovní skupina matematické biologie

Navigace: >> Ústav systémové biologie a ekologie >> Sektor fyzikální biologie >> Oddělení biologické dynamiky >> Pracovní skupina matematické biologie

Vedoucí vědecký pracovník
  Doc. RNDr. Ladislav Nedbal, DrSc.
Odborný pracovník výzkumu a vývoje, sam.
  Ing. Jan Červený
Technický pracovník
  Magda Mikšovská
Spolupracovník
  Anamika Mishra
Vedoucí
Doc. RNDr. Ladislav Nedbal, DrSc.
Tel.: +420 386361231
Fax: +420 386361231
lapi@nh.usbe.cas.cz
www.jiznicechy.org/en/index.php?path=mest/nhrady.htm

Adresa
Zámek 136, CZ-37333 Nové Hrady

Afiliace

Ústav systémové biologie a ekologie AVČR
Ústav fyzikální biologie Jihočeské Univerzity

Výzkum

The workgroup was constituted in Jan. 2006 in continuation of the earlier research by Laboratory of Applied Photobiology and Bio-Imaging. We used and developed experimental tools that yield multidimensional data fields required for construction and verification of mathematical models. Among the multidimensional techniques, privileged position is occupied by imaging techniques that constitute the core of systems biology experimental repertoire. We applied the imaging techniques on multiple hierarchical levels. Advanced mathematics is used to interpret new complex fluorescence transient. In order to explain the molecular mechanisms leading to the observed transients, we constructed an open web portal for modeling photosynthesis in dynamic light environment.

The new team members offer their expertise in using mathematical tools appropriate in dynamic biological systems analysis. Petr Chvosta applies methods used in stochastic thermodynamics and non-equilibrium energy conversion, Eva Pokojská focuses modeling and time-delay systems analysis.

Research perspective:
Our working hypothesis is that the spectrum of biological regulatory motifs that are responsible for emergent dynamic behavior is limited and is shared by various biological systems. We choose photosynthesis as the primary model system that is experimentally well accessible, and dynamically characterized. We continue the research of photosynthetic regulation by construction model networks that will be tested for analogies in other simple and complex systems. Description levels will range from molecular/cellular to individual/ populational interactions.

Odkazy

www.psi.cz

www.e-photosynthesis.org


References 2005-2007

Ladislav Nedbal, Jan Červený, Uwe Rascher, and Henning Schmidt: E-photosynthesis: A modeling approach to understand chlorophyll fluorescence transients and complex dynamic features of photosynthesis in fluctuating light. Photosynth.Res. Accepted.

Vácha, F., V. Sarafis, Z. Benediktyová, L. Bumba, J. Valenta, M. Vácha, Ch.-R. Sheue and L.Nedbal (2007) Identification of Photosystem I and Photosystem II enriched regions of thylakoid membrane by optical microimaging of cryo-fluorescence emission spectra and of variable fluorescence. Micron 38: 170-175.

Susanne Berger, Zuzana Benediktyová, Karel Matouš, Katharina Bonfig, Martin J. Mueller, Ladislav Nedbal, Thomas Roitsch (2006) Visualization of dynamics of plant-pathogen interaction by novel combination of chlorophyll fluorescence imaging and statistical analysis: Differential effects of virulent and avirulent strains of P. syringae and of oxylipins on A. thaliana (2007) J.Exp.Botany. 58 (4): 797-806.

Uwe Rascher and Ladislav Nedbal (2006) Dynamics of plant photosynthesis in fluctuating light. Curr.Opinion Plant Biol. 9: 671-678.

Karel Matous; Zuzana Benediktyova; Susanne Berger; Thomas Roitsch; Ladislav Nedbal (2006) Case study of combinatorial imaging: What protocol and what chlorophyll fluorescence image to use when visualizing infection of Arabidopsis thaliana by Pseudomonas syringae? Photosynth. Res. 90 (3): 243-253

Nedbal L. and Koblížek M. (2006) Chlorophyll fluorescence as a reporter on in vivo electron transport and regulation in plants. In: “Biochemistry and Biophysics of Chlorophylls” (Eds: B. Grimm, R. Porra, W. Rüdiger, H. Scheer), pp.507-519, Springer. ISBN 1-4020-4515-8.

Žabka, M., Drastichová, K., Jegorov, A., Soukupová, J. and Nedbal, L. (2006) Direct evidence of plant-pathogenic activity of fungal metabolites of Trichothecium roseum on apple. Mycopathologia 162 (1) 65-68.

Adamec, F., Kaftan, D. and Nedbal, L. (2005) Stress-induced filament fragmentation of Calothrix elenkinii (CYANOPHYCEAE) is facilitated by death of high-fluorescence cells. J.Phycology 41 (4): 835-839

Nedbal,L., Březina,V, Červený, J. and Trtílek, M. (2005) Photosynthesis in dynamic light: Systems biology of unconventional chlorophyll fluorescence transients in Synechocystis sp. PCC6803. Photosynth.Res. 84: 99–106

Nedbal, L., Marek, M. and Trtilek, M. (2005) Remote sensing of vegetation fluorescence can yield estimates of sunlight absorbed inside a complex canopy and sense the on/off status of the photosynthetic machinery. In: Remote sensing of vegetation fluorescence (Ed. Fletcher, K.) European Space Agency Publications Division, Noordwijk, Netherlands. ISSN 1022-6656