Nucleolus-associated chromatin in mother and daughter cells. The chromatin in the closest vicinity of nucleoli in HepG2H4-Dendra2 cells was photoconverted in S/early G2 phase. Labeled cells were observed by time-lapse imaging. An initial snapshot was taken just after conversion (left). The labeled cell entered mitosis 8 hours later and final snapshots of its daughter cells were taken 6.5 hours after mitosis (right). The labeled pattern formed in daughter cells differs widely from the pattern labeled in the mother cell. The two channels, the bright field and the merged image are shown.