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Centre for New Antivirals and Antineoplastics
Suported by the Ministry of Education, Czech Republic
 Centre for New Antivirals and Antineoplastics
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Publications List of Publications 2007

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79. Pomeisl, K.; Votruba, I.; Holý, A.; Pohl, R.: "Syntheses of Pyrimidine Acyclic Nucleoside Phosphonates as Potent Inhibitors of Thymidine Phosphorylase (PD-ECGF) from SD-lymphoma" Nucleosides, Nucleotides Nucleic Acids 2007, 26, 1025-1028.
78. Dejmek, M.; Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleoside analogues derived from 2-(hydroxymethyl)bicyclo[2.2.1]heptane" Collect. Czech. Chem. Commun. 2007, 72, 1523-1544.
77. Hřebabecký, H.; Dračínský, M.; Holý, A.: "Synthesis of novel carbocyclic nucleosides and Pro-Tides derived from 4-oxatricyclo[4.2.1.03,7]nonane-9-methanol" Collect. Czech. Chem. Commun. 2007, 72, 1331-1349.
76. Zápotocký, M.; Hanzalová, J.; Starková, J.; Votruba, I.; Holý, A.; Otová, B.: "Experimental Therapy with 9-[2-(Phosphonomethoxy)ethyl]- 2,6-diaminopurine (PMEDAP): Origin of Resistance" Folia Biologica (Praha) 2007, 53, 79-84.
75. Nencka, R.; Votruba, I.; Hřebabecký, H.; Jansa, P.; Tloušťová, E.; Horská, K.; Masojídková, H.; Holý, A.: "Discovery of 5-Substituted-6-chlorouracils as Efficient Inhibitors of Human Thymidine Phosphorylase" J. Med. Chem. 2007, 50, 6016-6023.
74. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: 2. Symmetrical 2-{[bis(phosphono)methoxy]methyl}ethyl derivatives of purines and pyrimidines" Collect. Czech. Chem. Commun. 2007, 72, 965-983.
73. Potměšil, P; Holý, A.; Kmoníčková, E.; Křížková, J.; Zídek, Z.: "Acyclic nucleoside phosphonate antivirals activate gene expression of monocyte chemotactic protein 1 and 3" J. Biomed. Sci. 2007, 14, 59-66.
72. Duraffour, S.; Snoeck, R.; Krečmerová, M.; van Den Oord, K.; De Vos, R.; Holý, A.; Crance, J.-M.; Garin, D.; De Clercq. E.; Andrei, G.: "Activities of several classes of acyclic nucleoside phosphonates against camelpox virus replication in different cell culture models" Antimicrob. Agents Chemother. 2007, 51, 4410-4419.
71. Krečmerová, M.; Holý, A.; Pohl, R.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: Synthesis and antiviral activity" J. Med. Chem. 2007, 50, 5765-5772.
70. Kožíšek, M.; Bray, J.; Řezáčová, P.; Šašková, K.; Brynda, J.; Pokorná, J.; Mammano, F.; Rulíšek, L.; Konvalinka, J.: "Molecular Analysis of the HIV-1 Resistance Development: Enzymatic Activities, Crystal Structures, and Thermodynamics of Nelfinavir-resistant HIV Protease Mutants" J. Mol. Biol. 2007, 374, 1005-1016.
69. Bambuch, V.; Otmar, M.; Pohl, R.; Masojídková, M.; Holý, A.: "C-Functionalization of 9-deazapurines by cross-coupling reactions" Tetrahedron 2007, 63, 1589-1601.
68. Krečmerová, M.; Holý, A.; Pískala, A.; Masojídková, M.; Andrei, G.; Naesens, L.; Neyts, J.; Balzarini, J.; De Clercq, E.; Snoeck, R.: "Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds" J. Med. Chem. 2007, 50, 1069-1077.
67. Renders, M.; Emmerechts, G.; Rozenski, J.; Krečmerová, M.; Holý, A.; Herdewijn, P.: "Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase" Angew. Chem. Int. Ed. 2007, 46, 2501-2504.
66. Lebeau, I.; Andrei, G.; Krečmerová, M.; De Clercq, E.; Holý, A.; Snoeck, R.: "Inhibitory activity of three classes of acyclic nucleoside phosphonates against murine polyomavirus and primate SV 40 strains" Antimicrob. Agents Chemother. 2007, 51, 2268-2273.
65. Krečmerová, M.; Holý, A.; Masojídková, M.: "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position" Collect. Czech. Chem. Commun. 2007, 72, 927-951.
64. Doláková, P.; Masojídková, M.; Holý, A.: "Efficient Synthesis of Pyrimidinecarbonitriles and Their Derivatives" Heterocycles 2007, 71, 1107-1115.
63. Vrbková, S.; Dračínský, M.; Holý, A.: "Bifunctional acyclic nucleoside phosphonates: synthesis of chiral 9-{3-hydroxy[1,4-bis(phosphonomethoxy)]butan-2-yl} derivatives of purines" Tetrahedron: Asymmetry 2007, 18, 2233-2247.
62. Kmoníčková, E.; Melkusová, P.; Farghali, H.; Holý, A.; Zídek, Z.: "Nitric oxide production in mouse and rat macrophages: A rapid and efficient assay for screening of drugs immunostimulatory effects in human cells" Nitric Oxide-Biol. Chem. 2007, 17, 160-169.
61. Zídek, Z.; Kmoníčková, E.; Holý, A.: "Secretion of antiretroviral chemokines by human cells cultured with acyclic nucleoside phosphonates" Eur. J. Pharmacol. 2007, 574, 77-84.
60. Vávrová, K.; Hrabálek, A.; Mac-Mary, S.; Humbert, P.; Muret, P.: "Ceramide analogue 14S24 selectively recovers perturbed human skin barrier" Brit. J. Dermatol. 2007, 157, 704-712.
59. Mlčochová, P.; Plechanovová, A.; Bařinka, C.; Mahadeva, D.; Saldanha, C.; Rulíšek, L.; Konvalinka, J.: "Mapping of the active site of glutamate carboxypeptidase II by site-directed mutagenesis" FEBS J 2007, 274, 4731-4741.
58. Bařinka, C.; Rovenská, M.; Mlčochová, P.; Hlouchová, K.; Plechanovová, A.; Majer, P.; Tsukamoto, T.; Slusher, B. S.; Konvalinka, J.; Lubkowski, J.: "Structural Insight into the Pharmacophore Pocket of Human Glutamate Carboxypeptidase II" J. Med. Chem. 2007, 50, 3267-3273.
57. Hasník, Z.; Šilhár, P.; Hocek, M.: "Synthesis of (purin-6-yl)acetates and 6-(2-hydroxyethyl)purines via cross-couplings of 6-chloropurines with the Reformatsky reagent" Tetrahedron Lett. 2007, 48, 5589-5592.
56. Vávrová, K.; Lorencová, K.; Klimentová, J.; Novotný, J.; Hrabálek, A.: "HPLC method for determination of in vitro delivery through and into porcine skin of adefovir (PMEA)" J Chromatogr. B 2007, 853, 198-203.
55. Nobilis, M.; Pour, M.; Šenel, P.; Pavlík, J.; Kuneš, J; Vopršalová, M.; Kolářová, L.; Holčapek, M.: "Metabolic profiling of a potential antifungal drug, 3-(4-bromophenyl)-5-acetoxymethyl-2,5-dihydrofuran-2-one, in mouse urine using high-performance liquid chromatography with UV photodiode-array and mass spectrometric detection" J. Chromatogr. B 2007, 853, 10-19.
54. Kubát, P.; Lang, K.; Cígler, P.; Kožíšek, M.; Matějíček, M; Janda, P.; Zelinger, Z.; Procházka, K.; Král, V.: "Tetraphenylporphyrin-cobalt(III) Bis(1,2-dicarbollide) Conjugates: From the Solution Characteristics to Inhibition of HIV Protease" J. Phys. Chem. B 2007, 111, 4539-4546.
53. Pomeisl, K.; Holý, A.; Pohl, R.: "Pd-catalyzed Suzuki-Miyaura coupling reactions in the synthesis of 5-aryl-1-[2-(phosphonomethoxy)ethyl]uracils as potencial multisubstrate inhibitors of thymidine phosphorylase" Tetrahedron Lett. 2007, 48, 3065-3067.
52. Hlouchová, K.; Bařinka, C.; Klusák, V.; Šácha, P.; Mlčochová, P.; Majer, P.; Rulíšek, L.; Konvalinka, J.: "Biochemical characterization of human glutamate carboxypeptidase III" J. Neurochem. 2007, 101, 682-696.
51. Németh-Pongrácz, V.; Barabás, O.; Fuxreiter, M.; Simon, I.; Pichová, I.; Rumlová, M.; Zábranská, H.; Svergun, D.; Petoukhov, M; Harmat, V.; Klement, É; Hunyadi-Gulyás, É; Medzihradszky, K. F.; Kónya, E.; Vértessy, B. G.: "Flexible segments modulate co-folding of dUTPase and nucleocapsid proteins" Nucl. Acids Res. 2007, 35, 495-505.
50. Zábranská, H.; Tůma, R.; Kluh, I.; Svatoš, A.; Ruml, T.; Hrabal, R.; Pichová, I.: "The Role of the S-S Bridge in Retroviral Protease Function and Virion Maturation" J. Mol. Biol. 2007, 365, 1493-1504.
49. Bařinka, C.; Starková, J.; Konvalinka, J.; Lubkowski, J.: "A high-resolution structure of ligand-free human glutamate carboxypeptidase II" Acta Cryst. 2007, F63, 150-153.
48. Šácha, P.; Zámečník, J.; Bařinka, C.; Hlouchová, K.; Vícha, A.; Mlčochová, P.; Hilgert, I.; Eckschlager, T.; Konvalinka, J.: "Expression of glutamate carboxypeptidase II in human brain" Neuroscience 2007, 144, 1361-1372.
47. Nijhuis, M.; van Maarseveen, N. M.; Lastere, S.; Schipper, P.; Coakley, E.; Glass, B.; Rovenska, M.; de Jong, D.; Chappey, C.; Goedegebuure, I. W.; Heilek-Snyder, G.; Dulude, D.; Cammack, N.; Brakier-Gingras, L.; Konvalinka, J.; Parkin, N.; Kräusslich, H. G.; Brun-Vezinet, F.; Boucher, C. A. B.: "A Novel Substrate-Based HIV-1 Protease Inhibitor Drug Resistance Mechanism" PLoS Med 2007, 4, e36.