Group of Biochemistry of Antimetabolites

Birkuš, G., Kramata, P., Votruba, I., Otová, B., Otmar, M., and Holý, A. (1998) Nonproteolyzed form of DNA-polymerase from SD-lymphoma of Sprague-Dawley inbred rat: isolation and characterization. Collect. Czech. Chem. Commun. 63, 723-731.

Fojtová, M., Kovařík, A., Votruba, I., and Holý, A. (1998) Evaluation of the impact of S-adenosylhomocysteine metabolic pools on cytosine methylation of tobacco genome. Eur. J. Biochem. 252, 347-352.

Franěk, F., Holý, A., Votruba, I., and Eckschlager, T. (1998) Modulation of cell cycle progression and of antibody production in mouse hybridomas by a nucleotide analogue. Cytotechnology 28, 65-72.

Birkuš, G., Votruba, I., Holý, A., and Otová, B. (1999) PMEApp as a substrate toward replicative DNA polymerases α,δ, and ε*. Biochem. Pharamacol. 58, 487-492.

Krejčová, R., Horská, K., Votruba, I., and Holý, A. (1999) Isoenzymes of GMP kinase from L1210 cells: isolation and characterization. Collect. Czech. Chem. Commun. 64, 559-570.

Otová, B., Francová, K., Franěk, F., Koutnik, P., Votruba, I., Holý, A., Sladká, M., and Schramlová, J. (1999) 9-[2-(Phosphonomethoxy)ethyl]-2,6-diaminopurine (PMEDAP) - a potential drug against hematological malignancies - induces apoptosis. Anticancer Res. 19, 3173-3182.

Franěk, F., Holý, A., Votruba, I., and Eckschlager, T. (1999) Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines. Int. J. Oncol. 14, 745-752.

Votruba, I., Krečmerová, M., Hřebabecký, H., and Holý, A. (1999) Inhibitory potency of 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one nucleosides against uridine phosphorylase from mouse leukemic L1210 cells. Nucleosides & Nucleotides 18, 2551-2564.

Otová, B., Mráz, M., Mandys, V., Panczak, A., Schramlová, J., Votruba, I., Holý, A. (1999) Therapeutic effect of heat shock on T-cell lymphoma in inbred Sprague-Dawley rat. Folia Biologica (Praha) 45, 121-131.

Hocková, D., Hocek, M., Dvořáková, H., and Votruba, I. (1999) Synthesis and cytostatic Activity of nucleosides and acyclic nucleoside analogues derived from 6-(trifluoromethyl)purines. Tetrahedron 55, 11109-11118.

Bobková, K., Otová, B., Marinov, I., Mandys, V., Panczak, A., Votruba, I. and Holý, A. (2000) Anticancer effect of PMEDAP - monitoring of apoptosis. Anticancer Res. 20, 1041-1048.

Krejčová R., Horská K., Votruba I. and Holý A. (2000) Interaction of guanine phosphonomethoxyalkyl derivatives of with GMP kinase isoenzymes. Biochem. Pharmacol. 60, 1907-1913.

Hocek M., Holý A., Votruba I., and Dvořáková H. (2000) Synthesis and cytostatic activity of substituted 6-phenylpurine bases and nucleosides: application of the Suzuki-Miyaura cross-coupling reactions of 6-chloropurine derivatives with phenylboronic acids. J. Med. Chem. 43, 1817-1825.

Krejčová R., Horská K., Votruba I. and Holý A. (2000) Phosphorylation of purine phosphonomethoxyalkyl derivatives by mitochondrial AMP kinase (AK2 type) from L1210 cells. Collect. Czech. Chem. Commun. 65, 1653-1668.

Hocek M., Holý A., Votruba I. and Dvořáková H. (2000) Cytostatic 6-arylpurine nucleosides II. Synthesis of sugar-modified derivatives: 9-(2-deoxy-β-D-erythro-pentofuranosyl)-, 9-(5-deoxy-β-D-ribofuranosyl)- and 9-(2,3-dihydroxypropyl)-6-phenylpurines. Collect. Czech. Chem. Commun. 65, 1683-1688.

Malínský J., Koberna K., Staněk D., Masata M., Votruba I. and Raška I. (2001) The supply of exogenous deoxyribonucleotides accelerates the speed of the replication fork in early S-phase. J. Cell Sci. 114, 747-750.

Valeriánová M., Votruba I., Holý A., Mandys V. and Otová B. (2001) Antitumour activity of N⁶-substituted PMEDAP derivatives against T-cell lymphoma. Anticancer Res. 21, 2057-2064 (2001).

Bobková K., Gut I., Mandys V., Holý A., Votruba I., and Otová B. (2001) Antitumour activity of a combined treatment with PMEDAP and docetaxel in the Prague Inbred Sprague-Dawley/Cub Rat Strain Bearing T-Cell Lymphoma. Anticancer Res. 21, 2725-2731.

Hocek M., Holý A., Votruba I. and Dvořáková H. (2001) Cytostatic 6-arylpurine nucleosides III. Synthesis and structure-activity relationship study in cytostatic activity of 6-aryl-, 6-hetaryl and 6-benzylpurine ribonucleosides. Collect. Czech. Chem. Commun. 66, 483-499.

Otmar M., Masojídková M., Votruba I. and Holý A. (2001) An alternative synthesis of HPMPC and HPMPA diphosphoryl derivatives. Collect. Czech. Chem. Commun. 66, 500-506.

Holý A., Votruba I., Tloušťová E. and Masojídková M. (2001) Synthesis and cytostatic activity of N-[2-(phosphonomethoxy)alkyl] derivatives of N6-substituted adenines, 2,6-diaminopurines and related compounds. Collect. Czech. Chem. Commun. 66, 1545-1592.

Birkuš G., Votruba I., Otmar M., and Holý A.(2001) The interactions of 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) diphosphate with DNA polymerases α, δ and ε*. Collect. Czech. Chem. Commun. 66, 1698-1706.

Holý A., Votruba I., Masojídková M., Andrei G., Snoeck R., Naesens L., De Clercq E. and Balzarini J. (2002) 6-[2-(Phosponomethoxy)alkoxy]pyrimidines with antiviral activity. J. Med. Chem. 45, 1918-1929.

Birkuš G., Hájek M., Kramata P., Votruba I., Holý A. and Otová B. (2002) Tenofovir diphosphate is a poor substrate and a weak inhibitor of eukaryotic DNA polymerases α, δ and ε*. Antimicrob. Agents Chemother. 46, 1610-1613.

Koukalová B., Votruba I., Fojtová M., Holý A. and Kovařík A. (2002) The hypomethylation of CNG targets induced with dihydroxypropyladenine is transient and fully reversible in tobacco repetitive sequences. Theor. Appl. Genet. 105, 796-801.

Hocek M., Votruba I. (2002) Covalent analogues of DNA base-pairs and triplets. Part 2: Synthesis and cytostatic activity of bis(purin-6-yl)acetylenes, -diacetylenes and related compounds. Bioorg. Med. Chem. Lett. 12, 1055-1058.