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Selected Publications: |
Klima M, Chalupska D, Rozycki B, Humpolickova J, Rezabkova L, Silhan J, Baumlova A, Dubankova A, Boura E. (2017) Kobuviral Non-structural 3A Proteins Act as Molecular Harnesses to Hijack the Host ACBD3 Protein. Structure [PubMed] Humpolickova J#, Mejdrova I#, Matousova M, Nencka R,* Boura E.* (2017) Fluorescent Inhibitors as Tools To Characterize Enzymes: Case Study of the Lipid Kinase Phosphatidylinositol 4-Kinase IIIβ (PI4KB). J Med Chem. [PubMed] Mejdrova I#, Chalupska D#, Plackova P, Muller C, Sala M, Klima M, Baumlova A, Hrebabecky H, Prochazkova E, Dejmek M, Strunin D, Weber J, Lee G, Matousova M, Mertl�kova-Kaiserov� H, Ziebuhr J, Birkus G, Boura E,* Nencka R.* (2017) Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIβ (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology. J Med Chem. [PubMed] Hercik K, Kozak J, Sala M, Dejmek M, Hrebabecky H, Zbornikova E, Smola M, Ruzek D, Nencka R, Boura E. (2017) Adenosine triphosphate analogs can efficiently inhibit the Zika virus RNA-dependent RNA polymerase. Antiviral Res. [PubMed] 2016 Eisenreichova A, Klima M, Boura E. (2016) Crystal structures of a yeast 14-3-3 protein from Lachancea thermotolerans in the unliganded form and bound to a human lipid kinase PI4KB-derived peptide reveal high evolutionary conservation. Acta Crystallogr F Struct Biol Commun. [PubMed] Baumlova A, Gregor J, Boura E. (2016) The structural basis for calcium inhibition of lipid kinase PI4K IIalpha and comparison with the apo state. Physiol Res. [PubMed] Klima M, Tóth DJ, Hexnerova R, Baumlova A, Chalupska D, Tykvart J, Rezabkova L, Sengupta N, Man P, Dubankova A, Humpolickova J, Nencka R, Veverka V, Balla T, Boura E. (2016) Structural insights and in vitro reconstitution of membrane targeting and activation of human PI4KB by the ACBD3 protein. Sci Rep.[PubMed] 2015 Boura E, Nencka R. (2015) Phosphatidylinositol 4-kinases: Function, structure, and inhibition. Exp Cell Res. [PubMed] Klima M, Baumlova A, Chalupska D, Hřebabecký H, Dejmek M, Nencka R, Boura E. (2015) The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design. Acta Crystallogr D Biol Crystallogr. [PubMed] Mejdrová I#, Chalupská D#, Kögler M#, Šála M, Plačková P, Baumlová A, Hřebabecký H, Procházková E, Dejmek M, Guillon R, Strunin D, Weber J, Lee G, Birkus G, Mertlíková-Kaiserová H, Boura E*, Nencka R*. (2015) Highly Selective Phosphatidylinositol 4-Kinase IIIβ Inhibitors and Structural Insight into Their Mode of Action. J Med Chem.[PubMed] Dejmek M, Šála M, Hřebabecký H, Dračínský M, Procházková E, Chalupská D, Klíma M, Plačková P, Hájek M, Andrei G, Naesens L, Leyssen P, Neyts J, Balzarini J, Boura E, Nencka R. (2015) Norbornane-based nucleoside and nucleotide analogues locked in North conformation. Bioorg Med Chem.[PubMed ] 2014 Różycki B, Boura E. (2014) Large, dynamic, multi-protein complexes: a challenge for structural biology. J Phys Condens Matter. [PubMed] Baumlova A, Chalupska D, Róźycki B, Jovic M, Wisniewski E, Klima M, Dubankova A, Kloer DP, Nencka R, Balla T, Boura E. (2014) The crystal structure of the phosphatidylinositol 4-kinase IIα. EMBO Rep.[PubMed] Jović M, Kean MJ, Dubankova A, Boura E, Gingras AC, Brill JA, Balla T. (2014) Endosomal sorting of VAMP3 is regulated by PI4K2A. J Cell Sci. [PubMed] 2013 Nemecek D, Plevka P, Boura E (2013) Using cryoEM reconstruction and phase extension to determine crystal structure of bacteriophage ϕ6 major capsid protein. Protein J. [PubMed] Nemecek D, Boura E, Wu W, Cheng N, Plevka P, Qiao J, Mindich L, Heymann JB, Hurley JH, Steven AC. (2013) Subunit folds and maturation pathway of a dsRNA virus capsid. Structure. [PubMed] OLD Rozycki B, Boura E, Hurley JH, Hummer G. (2012) Membrane-elasticity model of Coatless vesicle budding induced by ESCRT complexes PLoS Comput Biol. [PubMed] Boura E, Ivanov V, Carlson LA, Mizuuchi K, Hurley JH. (2012) Endosomal Sorting Complex Required for Transport (ESCRT) complexes induce phase-separated microdomains in supported lipid bilayers. J Biol Chem. [PubMed] Baskaran S, Ragusa MJ, Boura E, Hurley JH. (2012) Two-Site Recognition of Phosphatidylinositol 3-Phosphate by PROPPINs in Autophagy. Mol Cell. [PubMed] Boura E, Rózycki B, Chung HS, Herrick DZ, Canagarajah B, Cafiso DS, Eaton WA, Hummer G, Hurley JH. (2012) Solution structure of the ESCRT-I and -II supercomplex: implications for membrane budding and scission. Structure [PubMed] Noinaj N, Easley NC, Oke M, Mizuno N, Gumbart J, Boura E, Steere AN, Zak O, Aisen P, Tajkhorshid E, Evans RW, Gorringe AR, Mason AB, Steven AC, Buchanan SK. (2012) Structural basis for iron piracy by pathogenic Neisseria. Nature [PubMed] Boura E, Hurley JH. (2012) Structural basis for membrane targeting by the MVB12-associated ß-prism domain of the human ESCRT-I MVB12 subunit. PNAS [PubMed] Boura E, Rozycki B, Herrick D, Chung HS, Vecer J, Eaton W, Cafiso D, Hummer G, and Hurley JH. (2011) Solution structure of the ESCRT-I complex by small angle x-ray scattering, EPR, and FRET spectroscopy PNAS [PubMed] Hurley JH, Boura E, Carlson LA, Rozycki B. (2010) Membrane budding. Cell [PubMed] Im YJ, Wollert T, Boura E, Hurley JH. (2009) Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell. [PubMed] Boura E, Silhan J, Herman P, Vecer J, Sulc M, Teisinger J, Obsilova V, Obsil T. (2007) Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding. J Biol Chem. [PubMed] Boura E, Liebl D, Spísek R, Fric J, Marek M, Stokrová J, Holán V, Forstová J. (2005) Polyomavirus EGFP-pseudocapsids: analysis of model particles for introduction of proteins and peptides into mammalian cells. FEBS Lett. [PubMed]
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